NewFor the first time, research has tracked the spread and replication the protein tau.
AggregatesDevelopment of tau and beta-amyloid is facilitated by the protein beta amyloid. Alzheimer’s disease.
TheInternational study published in the Journal at the End of Last Month Science AdvancesScientists at the UniversityOf Cambridge.
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InIt was stated that the authors were able to quantify the rate at which they replicate in human brains by combining chemical kinetics and measurements of tau aggregates (or “seeds”) across brain regions.
After developing a mathematical model to simulate the progression of the disease and using five different methods of tau quantification – ranging from postmortem seed amplification assays to tau PET (positron emission tomography) scans of the brains of living individuals – the researchers said that they had obtained comparable rates in several different datasets.
“OurResults suggest that from BraakStage III and beyond, local replication is the main process that controls the rate of accumulation of tau within neocortical areas. The number of seeds doubles only every ∼5 years. ThusLimiting local replication is the best strategy to limit tau accumulation. [Alzheimer’s disease]They wrote:
BraakThe stage III refers the third of six stages in the BraakMethods used to classify the severity of pathology Alzheimer’s disease.
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PreviouslyAs Medical News TodaySome believed that Alzheimer’sDisease progresses when tau seeds spread into unaffected areas of the brain.
TheseThe publication states that these findings could be important in the development and application of new therapies.
Alzheimer’sThe most common type is dementia caused by disease.
In2020: As many as 5.8 Million AmericansThey were living with Alzheimer’sAccording to the U.S. CentersFor Disease ControlAnd Prevention (CDC). ThatThe number of people living in the area is expected to triple between 2060 and 2060.
ScientistsWe don’t yet know the causes. Alzheimer’sAge is the most well-known risk factor for disease.
ChangesBrain damage can occur years before symptoms are apparent.
TheThe brain shrinkage caused by loss of nerve cells can interfere with cognition and memory.
Source: Fox News